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A V20 is an internal combustion engine in V configuration, having 20 cylinders. Engines of this number of cylinders are not common.

A V20 configuration is used by several large diesel engines.

In railroad locomotive use, V20 engines were used in the 1960s vintage EMD SD45, which was fitted with a 20-cylinder EMD 645E3 engine. That engine name is based on the volume of each cylinder in cubic inches. In this case 645 inch³ (10.6 L) for each of 20 cylinders (a total of 211 L). Power output is 3,600 hp (2.7 MW) in turbocharged form.

V20 diesel engines have also been used in marine applications; Mercedes-Benz has produced one such.