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TATA box
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TATA box

A TATA box is a DNA sequence found in the promoter region of most genes (it is considered to be a promoter sequence). It is the binding site of either transcription factors or histones (binding of one blocks binding of the other). It has the DNA sequence 5' TATAAAA 3'.

Many genes lack a TATA box and use an initiator element or downstream core promoter instead.

Location

Found in the promoter region of most genes, about 25 bps upstream from the start site of transcription. It is usually adjacent to GC rich sequences.

Binding of histones

The binding of histones involves the N-terminal tail of H4.

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