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H4 is a class of histone. H4 is part of the histone octamer. The N-terminal tail of H4 plays a role in freeing TATA boxes from nucleosomes. When activator proteins or their accessories bind to a specific spot on the N-terminal tail of H4, the binding may induce a conformational change in the histone, which may lead to the temporary ejection of H2A and H2B from the nucleosome. Displacement of H2A and H2B could cause some of the DNA to become available for transcription. After passage of the RNAP, the histone octamer may reasseble.

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