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Glycogenesis is the formation of glycogen from glucose. Glycogen is synthesized depending on the amount of glucose and ATP present. When glucose and ATP are present in relatively high amounts, then insulin promotes the glucose conversion into glycogen for storage in liver and muscle cells.

In the synthesis of glycogen, one ATP is required per glucose included into the polymeric branched structure of glycogen. It is glucose-6-phosphate that initiates the process of Glycogenesis. Glucose-6-phosphate is synthesized directly from glucose or as the end product of Gluconeogenesis.