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Beefalo are a fertile cross-breed of domestic cattle and the American bison, often called buffalo. They were developed beginning in the mid-1800s, with the present beefalo being a combination of 3/8 Bison, 5/8 cattle. Beefalo meat, like bison meat, is lower in fat and cholesterol and higher in fiber than beef. Beefalo are better able to tolerate cold and need less assistance calving than cattle while having domestic cattle's docile nature and fast growth rate. They are also thought to produce less damage to rangeland than cattle.

Unfortunately, the high price of this meat had done little to generate popularity, and it remains a menu item for only a select few consumers.